Inactivation of Nf-κb P50 Leads to Insulin Sensitization in Liver through Post-translational Inhibition of P70s6k
نویسندگان
چکیده
Zhanguo Gao, Jun Yin, Jin Zhang, Qing He, Owen P. McGuinness and Jianping Ye From Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, 37232. Running head: Regulation of S6K by NF-kB Address correspondence to: Jianping Ye, MD, 6400 Perkins Road, Baton Rouge, LA 70808. Fax: 225-763-3030. E-mail: [email protected]
منابع مشابه
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.
In this study, we investigated the metabolic phenotype of the NF-kappaB p50 knock-out (p50-KO) mice. Compared with wild type mice, the p50-KO mice had an increase in food intake, but a decrease in body fat content. On chow diet, their blood glucose dropped much more than the wild type (WT) mice in the insulin tolerance test. Their glucose infusion rate was 30% higher than that of the WT mice in...
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